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Structural representations were created using Pymol v.2.4.1

Smad signaling antagonizes STAT5-mediated gene transcription and mammary epithelial cell differentiation

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RNA was reverse transcribed into cDNA using the Hifair III 1st Strand cDNA Synthesis Kit

As such, the known information suggests that epigenetic reprogramming may contribute to the phenotypic transformation of immune cells and favor the development of NAFLD by influencing their inflammatory environment [54, 55]