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These protective effects are mediated through antioxidant properties, enhancement of blood flow and oxygen delivery, and modulation of inflammatory cytokine production

While mice and rats are convenient laboratory animal models, the fact that they are nocturnal animals that normally experience completely different UV exposure levels to humans means that the role of UV light exposure in cataract development in rodents must be carefully interpreted with respect to cataract formation in the human lens

The activating mutations within the kinase domain of mTOR can directly increase mTOR signaling

Andreeff M , Darzynkiewicz Z, Cirrincione C, Groshen S, Melamed MR

doi: 10.1186/s40478-023-01624-8 27 De La MonteS