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The collagen fiber type transitions gradually from the outer to the inner layersthe outer layer is primarily composed of tension-resistant type I collagen, while moving inward, it gradually mixes with type II collagen extending to the edge of the nucleus pulposus, forming a tough ring structure that provides mechanical support to the disc by restricting NP displacement and resisting compressive loads

Dimethyl itaconate is effective in host-directed antimicrobial responses against mycobacterial infections through multifaceted innate immune pathways

Hu Q, Zhang H, Gutirrez Corts N, Wu D, Wang P, Zhang J, et al

Stem Cells 27 , 22202228 (2009)

1 April 2001