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Here are some key immunological features associated with SLE: (i) Increased production of autoantibodies, including antinuclear antibodies (ANA), anti-double-stranded DNA antibodies (anti-dsDNA), anti-phospholipid antibodies, and other specified autoantibodies

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2 , 49 , 50 The MC1R gene exhibits significant polymorphism, with 55 single-nucleotide polymorphisms (SNPs) identified across seven geographically distinct human populations

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