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What This Means for Experimental Design IGFBP Interactions: Degree of Reduction Differs Both analogs reduce IGFBP binding, but not equally: IGF-1 LR3 achieves approximately 1,000-fold reduction in affinity for all major IGFBPs

10.1016/j.devcel.2015.09.008 51 DanaiL

Sublingual absorption is at least partially passive, it doesn't require stomach acid or intrinsic factor, and high doses leverage a small passive-diffusion absorption pathway that operates independently of the intrinsic factor system

Additionally, it has been suggested that optimizing parameters, such as phospholipid composition, PEGylation, and liposome modification, can further promote drug bioavailability in brain tissues

Neither is true