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The evolutions in the field of drug discovery open the way to a new generation of senolytic therapies, such as immunological approaches (CAR-T cells, Antibody-Drug Conjugated or vaccines), which require preliminary steps of research to identify markers specifically expressed on senescent cells, demonstrating promising specific effects

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NAD + homeostasis The NAD + molecule is composed of a pyridine, derived from NAD + precursors such as tryptophan (Trp) or nicotinamide (NAM) 20 , a purine, and a 5-phospho-d-ribosyl-1,-disphosphate (PRPP) component 21

Pyridoxine is essential for the development of the brain and spinal cord