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Cognitive protection of sinomenine in type 2 diabetes mellitus through regulating the EGF/Nrf2/HO-1 signaling, the microbiota-gut-brain axis, and hippocampal neuron ferroptosis

ONeill, L

demonstrated antioxidant defense mechanisms were disordered by elevated ROS in stimulated memory CD4 + T cells from psoriasis patients [99]

10.1038/mp.2011.52 Mol

Through technological innovations (CRISPR screening for resistance targets, real-time death process monitoring via nanoprobes) and adaptive clinical trial designs (basket trials stratified by ACSL4 activity), the vision of on-demand death induction tailored to individual molecular profiles is advancing, heralding a new era of precision oncology with transformative potential for global cancer care (Table 5)