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This situation contrasts sharply with approved peptide drugs, which must meet rigorous quality standards

10.1016/j.cell.2015.04.042 Summary Keywords intervertebral disc, low back pain, MSC, regenerative medicine, microenvironment, niche, extracellular vesicles (EVs), disc progenitor cells Citation Wang H, Xu A, Hua W, Mao J, Zhang J, Ma X and Lu L (2025) Stem cell-based strategies for intervertebral disc regeneration in degenerative microenvironments: challenges and solutions

Patients should be instructed to rotate injection sites to minimize the risk of injection site reactions and to avoid injecting into areas that are tender, bruised, red, or hard

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