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However, in a subanalysis of participants with low vitamin B 12 status at baseline (n= 101), the B-vitamin supplementation slowed the decline in bone mineral density (total hip and femoral neck but not lumbar spine) (116)

Current attempts such as the CobaSorb Test and tests employing a detectable non-radioactive form of B12 may prove to be reasonable alternatives for the original Schillings Test, and thereby help to solve the most important question: Will this patient need a lifelong treatment with pharmacological doses of B12

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10.1001/jama.295.10.1152