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Early vitamin E supplementation in young but not aged mice reduces A levels and amyloid deposition in a transgenic model of Alzheimer's disease

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Conclusion: ScRNA-seq and single cell IMC determined that steatotic livers have immunosuppressive TIME compared to non-steatotic livers, which is regulated by M2TAMs, T cells, CAFs, and CRC cells with the expression of PD-L1, PD1, CD44, and YAP