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A broader investigation into alternative regulatory modalities, such as ligand-dependent cytoplasmic sequestration or post-translational modifications, could provide new insights into nuclear receptor biology and help address the challenges of deorphanization

They help regulate cell absorption or excretion of nutrients and wastes, and can be broken down for use as energy when needed

Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis

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CRISPR screens are helping to identify new targets and learnings from years of using CAR-T to treat liquid tumors like leukemia are helping researchers design CAR-T therapies to tackle solid tumors.In the past few years, a number of clinical trials have begun testing CAR-T immunotherapy in patients whose disease is not adequately controlled with traditional treatments