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Finally, the types, locations, and stages of brain tumors, as well as the therapeutic regimen are also important factors to be considered to hypothesize the desired effect (pro/antioxidant) from an exogenous antioxidant in brain cancer treatment

In summary, the core of the nicotine rewarding mechanism lies in its profound impact on dopaminergic transmission in the mesolimbic system, achieved through complex direct and indirect pathways

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In macrophages, mtROS are known to mediate IKK complex activation by forming a disulfide bridge between Cys54 and Cys347 on NEMO, which is crucial for IKK complex activation (115)

& Pelletier,