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Hence, pharmaceuticals that target the NRF2 pathway can influence multiple pathways involved in the neurodegenerative process, and therefore hold potential to become therapies that can significantly modify the course of neurodegenerative diseases

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Nonetheless, the screening, detection and verification of these targets remain a challenging task and recent studies showing protein hydroxylation by PHDs and FIH used a broad spectrum of different techniques to analyze and confirm these new substrates, see Table 1

A gradual increase on to activity of GT was reported with the increasing on the reaction temperature, till maximum activity at 3742 C followed by a dramatic decrease on its activity at 6070 C (Fig