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Abstract Autism spectrum disorder (ASD) is classified as early-emerging developmental divergences distinguished by aberrant interpersonal interactions as well as inflexible, stereotyped activities with no definitive treatments targeting the core symptoms

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In contrast, the Grooved Pegboard Test, a commonly used measure of fine motor coordination and dexterity, demonstrates a broader dynamic range and has been shown to decline progressively with disease worsening, making it a more reliable response biomarker in longitudinal studies [512]

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