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Additionally, aging is linked to malfunctions in the autophagy process

What it does establish is biological plausibility for restoration: putting back what the body has lost is a more conservative pharmacological proposition than overdriving a healthy system

Blockade of autophagy reduces pancreatic cancer stem cell activity and potentiates the tumoricidal effect of gemcitabine

40 In addition to the above regulatory factors, crosstalk between Wnt/-catenin and other pathways also regulates canonical Wnt signalling in different ways (Table 4)