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3 Exercise as a modulator of aging Regular exercise is widely recognized as a powerful modulator of the aging process (Figure 1, exercise modulates multiple biological pathways implicated in aging

Trypanosomatidae Diseases: from the Current Therapy to the Efficacious Role of Trypanothione Reductase in Drug Discovery

monnieri hexane extract at a dose of 7 and 10 mg/ml could extend the median and maximum lifespan and reduce the effects of aging in aged worms, thus, proving that BM hexane extract can be a potential prophylaxis agent against oxidative and mitochondrial damage and can be used as a therapeutic agent in aged patients (125)

Specifically, BM-MSCs could significantly reduce the protein level ofinducible nitric oxide synthase (iNOS), an oxidative stress marker, in rat seminiferous epithelium, thereby alleviating oxidative stress damage to testicular tissue (80)

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