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First, the upregulation of Psme3, hnRNP K, and H2BC3 suggests that the ATM/P53-dependent DNA damage checkpoint is fully activated and that G 2 /M cell cycle arrest is maintained for several hours until repair is effected and cells reenter the cell cycle 26

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Otoscopic examination of the ear canal and ear drum can reveal middle ear causes of hearing loss (eg, cerumen impaction, middle ear infection, or perforated ear drum)