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Furthermore, GSH plays a dual inhibitory role in PDAC, inhibiting cuproptosis by chelating copper ions and inhibiting ferroptosis as a substrate for GPX4, thereby serving as a key metabolic node that connects the two pathways [123]

During the inf lammatory immune response, excess ammonia increases production of inflammatory NO by contributing more nitrogen

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Vance C, Rogelj B, Hortobgyi T et al (1979) (2009) Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6

20 Pharmacological inhibition or genetic absence of GPX4 induce ferroptosis in mouse tumor xenografts