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Oxidative stress in erythrocytes During their life span, the erythrocytes are continuously exposed to high O 2 tension, due to their primary function as gas carriers, and are unable to synthesize new or repair damaged proteins, due to the lack of nucleus and other organelles

doi: 10.1371/journal.pone.0082555 153 FoellDWittkowskiHKesselCLukenAWeinhageTVargaGet al

The pain from a vaccine injection is due to the bodys inflammatory response to the vaccine, which can vary in intensity depending on the type of vaccine, with some vaccines like the COVID-19 (especially Moderna) and Shingrix causing more pain than others

However, in June 2022, the FDA "conditionally approved" pimobendan as treatment of dogs diagnosed with Stage B2 of MVD

miR, micro RNA