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Therefore, once substances enter the CSF, they can easily diffuse across the ependymal layer and into the brain

Studies have shown that early treatment with resveratrol can significantly reduce hearing thresholds at all frequencies, and can reduce the mRNA expression levels of pro-apoptotic genes Bax and Bak, and increase the mRNA expression level of anti-apoptotic genes Bcl-2 and Bcl-xL, but there was no significant difference in hearing levels between the late treatment group and the control group [114]

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Lysosomal acid lipase deficiency impairs regulation of ABCA1 gene and formation of high density lipoproteins in cholesteryl ester storage disease

These compounds improved metabolic profiles, reduced hepatic steatosis and inflammation (e.g., lowered cytokine levels), and inhibited fibrosis by decreasing extracellular matrix deposition, highlighting CB1 blockade as a mechanism to mitigate NAFLD without central nervous system side effects (Yang et al