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Such direct inhibitory action appears surprising for a peptide thought to be primarily involved in sleep promotion

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116,126 Specifically, CCS-overexpressing SOD G93A mice exhibit significantly decreased COX activity when these mice reached the end stage of disease, whereas SOD G93A mice not overexpressing CCS had no apparent decrease in COX activity at the same stage, 126 supporting the hypothesis that overexpressing CCS increases the delivery of Cu to SOD1 while reducing the delivery of Cu to other enzymes (e.g., mitochondrial cytochrome c oxidase), thus leading to additional toxic effects

Pickart named it GHK-Cu, and what followed was a systematic investigation that would span decades and reveal biological activities that seemed almost too good to be true

FBXL3, beyond targeting CRY proteins, also indirectly influences REV-ERB-mediated repression of BMAL1 and CRY1 , as elevated REV-ERB levels in FBXL3 -mutant mice enhance transcriptional repression (Shi et al., 2013