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BOX1: Complexity of genetic alterations and metabolism in PDAC In addition to the most frequent oncogenic somatic mutation KRAS , a high percentage of patients carry inactivating somatic mutations in the tumor suppressors cyclin-dependent kinase inhibitor 2 A ( CDKN2A ), tumor protein 53 ( TP53 ), and SMAD family member 4 ( SMAD4 ) [113,114,115], reinforcing their roles during PanIN-to-PDAC [116]

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PMID: 37 GregoryLGCaustonBMurdochJRMathieSAO'DonnellVThomasCPet al

To boost the effect of SAG and restore glutathione levels, a precursor of this antioxidant is also available to buy from the SuperSmart catalog: N-Acetyl Cysteine (NAC), a particular form of L-cysteine