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In studies on melanoma cells in vitro and in vivo , elevated GGT activity has been found to accompany an increased invasive growth [45, 47, 48], and a positive correlation has been described between GGT expression and unfavourable prognostic signs in human breast cancer [49]

Thus, through a series of linked steps, intracellular NAD(P)H can act as substrate for superoxide generation on the cell surface

In the canonical pathway, activated inflammasome sensors (NLRP1, NLRP3, NLRC4, and AIM2) form the inflammasome complex with the adapter apoptosis-associated speck-like protein containing a CARD (ASC) for caspase 1 activation

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