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Because of the dominant character of SOD1-dependent ALS, SOD1 WT is present in the majority of fALS cases

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Pro-inflammatory macrophages commonly increase glycolysis and reprogram the TCA cycle and mitochondrial electron transport chain to support rapid cytokine production, reactive oxygen species (ROS) generation, and antimicrobial activity, whereas pro-resolving macrophages more often engage in mitochondrial respiration, fatty acid oxidation, and biosynthetic programs linked to efferocytosis and tissue repair ( Figure 1 )