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Low levels of vitamin D have been associated with low mood and behavioral difficulties in children, and psychological difficulties, such as feelings of anxiety, in adults

[246] demonstrated that intravenous curcumin protected against BBB disruption, brain edema, and neuroinflammation by inhibiting the iNOS/NO pathway in MCAO rats

The peer-reviewed review found that compounds like psilocybin can reduce pro-inflammatory cytokines such as TNF, IL-6, and CRP, both acutely and up to 7 days after a single dose