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Here we adapt this complementation assay to our recently described VE mapping framework and use it to generate comprehensive functional maps of CBS missense variation with low or high levels of vitamin B 6

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Finally, melatonin promotes the elongation of the autophagosome by relieving the repressive effect of p53 on BNIP3 (Zhou et al., 2018b) and enhancing the level of LC3- ( On the other hand, melatonin could also inhibit autophagy to keep the mitochondrial redox state in balance in some cases