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Adjuvant chemotherapy with or without bevacizumab in patients with resected non-small-cell lung cancer (E1505): an open-label, multicentre, randomised, phase 3 trial

Initial mitochondrial ROS production triggers calcium release from intracellular stores, which, in turn, further stimulates mitochondrial ROS production while activating calcium-dependent proteases and phospholipases ( Cell death pathways Hair cell death proceeds through multiple interacting mechanisms, with the dominant pathway determined by drug concentration, exposure duration, and cellular stress levels

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