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In cultured cells, anthracyclines like doxorubicin and daunorubicin bind to DNA and inhibit HIF-1 and HIF-2 binding as well as the angiogenic growth factors expression, which interferes with tumor vascularization and growth (Figure 5) [104]

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doi: 10.3389/fgene.2022.1079455 Received 05 November 2022 Accepted 28 December 2022 Published 09 January 2023 Volume 13 - 2022 Edited by Qinghai Huang, Changhai Hospital, China Reviewed by Alexey V

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