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School of the Arts Clinton Bradley, Olathe, Kansas

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10.3390/ijms23147977 75 DoctrowS

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The CPT1A/c-Myc positive feedback loop further enhances the cellular antioxidant capacity by activating the NRF2/GPX4 system and reduces the amount of phospholipid polyunsaturated fatty acids through ACSL4 downregulating, thereby suppressing ferroptosis in CSCs

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This mechanism is one reason why chronic venous insufficiency is such a major driver of venous leg ulcers

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