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Nitric oxide was found to be overexpressed in patients with UC, especially in the colonic mucosa leading to pathological changes in tissues, DNA damage, production of inflammatory cytokines, inhibition of the repair process, and elevating the risk of conversion of UC to colon cancer [Citation30,Citation31]

Potential role of epigenetic mechanism in manganese induced neurotoxicity

95% CI: 0.015, 0.219) and OC (: 0.149

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