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Given that DAB2IP has been demonstrated to effectively inhibit key pro-inflammatory signaling pathways such as NF-B and TNF, we speculate that DAB2IP may, through its anti-inflammatory function, negatively regulate the formation and development of tertiary lymphoid organs within plaques, thereby mitigating abnormal local immune responses

Stough, C

Finally, centrifuged at 10,000 g for 10 min at room temperature, and transferred 200 L of the supernatant to a 96-well plate for detection using a microplate reader (ThermoFisher Scientific, USA)

In particular, curcumin increases the expression of GCL and other detoxifying enzymes via the activation of the nuclear factor E2-related factor 2 (Nrf2)-dependent pathway