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The proportion of p--syn in the normal state is very low, and an abnormal increase in p--syn induces the formation of pathological aggregates that contribute to neurotoxicity [10]

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Combined sub-threshold doses of 2.5 ng/ml + 10 "13 M Dihexa and 2.5 ng/ml + 10 "13 M Nlel-AnglV phenocopied the effects of each agonist at its biologically active dose alone (mean S.E.M

Technical References and Further Reading By contrast, Briere DA, et al

NNMT was confirmed to be upregulated in aged versus young mouse skeletal muscle