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Results: We generated a representative human model of ALGS reproducing ductopenia in a controlled and reproducible experimental environment

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In addition, there is a higher susceptibility of Nrf2 -null mice to liver injury [42], while the semi-synthetic oleanane triterpenoid compounds that activate Nrf2 were shown to be hepatoprotective in different models of liver disease (nonalcoholic fatty liver disease, acetaminophen-induced liver injury, and immune-mediated hepatotoxicity) that have been tested [40, 43,44,45]