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For example, in certain lung pathophysiological conditions, oxygenation of terminal airways becomes uneven, such that this temporal and spatial variance in oxygen abundance essentially determines the survival of the lung cells via oxygen-dependent activation of cell regulators and genes critical to defending their structural/functional characteristics [5, 8, 10, 13, 14, 1618, 2123, 26, 27]

Hence, there is an unmet need to provide current and future head and neck cancer patients with preventative therapies to protect salivary gland function

The mPTP opens in response to calcium and/or oxidative stress and allows transit of molecules of up to 1,500 Da from inside mitochondria to the cytosol

Chem Bio Eng Rev 4:339359 Brenner M, Benavides S, Mahon SB, Lee J, Yoon D, Mukai D, Viseroi M, Chan A, Jiang J, Narula N, Azer SM, Alexander C, Boss GR (2014) The vitamin B12 analog cobinamide is an effective hydrogen sulfide antidote in a lethal rabbit model

A doctor injects the chemical into a vein in your arm, and you return 24 to 72 hours later to finish the procedure