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Nutrients (2013) 5(4):121840

For example, dietary polyphenols (such as anthocyanins and ellagitannins in berries) can activate the AMPK/mTOR signaling pathway to inhibit NF-B-mediated secretion of pro-inflammatory cytokines like IL-1 and TNF- in microglia, thereby improving the neuroinflammatory microenvironment associated with metabolic disorders such as diabetes

From a therapeutic perspective, the superior efficacy of PTC299 in our models likely reflects its greater potency and ability to inhibit DHODH in metabolically active tumor subsets