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Sci Rep 10 , 11561 (2020)

In: Morava E, Baumgartner M, Patterson M, Rahman S, Zschocke J, Peters V (eds) JIMD reports, vol 26

Alveolar macrophages (AMs) mainly rely on mitochondrial oxidative phosphorylation (OXPHOS) in the resting state, but during sepsis (39), they switch to glycolysis through HIF-1-mediated metabolic reprogramming, resulting in excessive secretion of pro-inflammatory cytokines (40)