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Stefkovich, M., Arao, Y., Hamilton, K

New Views on PII Signaling: From Nitrogen Sensing to Global Metabolic Control

According to Krithika Srikanthan et al., activation of the Na/K-ATPase signal cascade exacerbates obesity, diabetes, dyslipidemia, and atherosclerosis, and these conditions are all related to the imbalance of OS ( The nuclear factor erythroid 2-related factor 2 (NRF2) pathway is closely related to antioxidant effects and is activated at the onset of OS ( Relationship Between Increased ROS Caused by Hyperglycemia and Cardiovascular Dysfunction Hyperglycemia (high levels of blood glucose) leads to increased production of ROS, which ultimately leads to vascular dysfunction ( Another question that needs resolution is how does high blood sugar level trigger OS and lead to cardiovascular dysfunction

In general, the efficient radiationless deactivating compounds are derivatives of benzophenone, substituted with hydroxyl and/or alkoxy groups, mostly in position(s) 2 and/or 4