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What stood out: CagriSema achieved 23.0% weight loss at 84 weeks (efficacy estimand) Tirzepatide achieved 25.5% On the treatment-regimen estimand, weight loss was 20.2% vs 23.6% Primary endpoint not met: CagriSema did not demonstrate non-inferiority vs tirzepatide on weight loss at 84 weeks Why this matters This is a reminder that in obesity pharmacotherapy, very effective and best-in-class are not the same conversation

If you are taking other medications, let your doctor know before starting either peptide

in Methods in enzymology Vol

Ethics statement The studies involving humans were approved by Mayo Clinic Center for Regenerative Biotherapeutics Biotrust Oversight Group Committee (Approval Number: IRB # 14001464)

Our aim is not to produce a list of defective pathways but to identify common patterns/pathways which may underpin a common etiology in these three conditions