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Moreover, oxidative damage to mitochondrial DNA (mtDNA) results in the release of mtDNA into the cytosol, where it triggers Toll-like receptor 9 (TLR9) and inflammasome activation, leading to further production of pro-inflammatory cytokines and recruitment of immune cells 67

Our results of the EF% (EF%: SMD: -4.13, 95% CI -5.56, -2.69, p = 0.00001) and FS% (FS%: SMD: -2.91, 95% CI -3.96, -1.86, p = 0.00001) are in agreement with having decreased values in mice induced with MI, as opposed to the mice treated with FGF-9 after inducing MI, which displayed an improvement in the left ventricular output measured by the elevation of the EF% and the FS% as parameters of cardiomyopathy function compared to the non-diabetic controls

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