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The contrast between IGF1 upregulation in PHH and INSR downregulation in HLO underscores the different stages and mechanisms of insulin resistance across cellular models of MASH, offering insights into disease progression and potential therapeutic targets

According to data from the Global Burden of Disease (GBD) study, the age-standardized growth incidence of PD in China reached 115.7% from 1990 to 2019significantly exceeding the global average

Chugani, Lawrence I

These multi-pathway metabolic therapeutics remain in the preclinical stage but show promising potential for further development

It has been reported that proteolytic enzymes can cause the debridement of wounds and the removal of necrotic tissue