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7 Following detachment from the primary tumour, the metastatic process comprises a sequence of steps, including cell invasion through the basement membrane into surrounding tissue, intravasation into blood vessels, survival and arrest in the circulatory system, extravasation through transendothelial migration, colonisation and the eventual formation of distant metastatic lesions (Fig

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Studies have shown that mice fed with rich iron diets showed upregulation of IR-related adipokines [52]

Following antigenic binding to the T-cell receptor, the strength of the immune response depends on the expression and interaction of costimulatory surface molecules on antigen presenting cells with those on T cells (68, 69)