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642 In a multicenter, randomized, double-blind, placebo-controlled phase-3 clinical trial conducted in China, acetyllevocarnitine hydrochloride treatment for 24 weeks significantly improved symptoms and somatosensory symptoms in patients with DPN, with a treatment effect of 65% higher than placebo

BDNF expression and secretion from microglia have been shown for both activated M1 and M2 phenotypes but also for non-activated M0 microglia (Coull et al

Kaschek, D., Mader, W., Fehling-Kaschek, M., Rosenblatt, M

USA 108 , 95609565 (2011)

We had demonstrated that circulating extracellular vesicles (EVs) and EV-protein composition were significantly associated with MetS-related factors in adult