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Due to the diminished capacity of tumor cells to take up aspartate compared to other metabolites [42, 52, 55, 113], this counteracting effect of the glutamine production of aspartate by HIF-1 can significantly inhibit the proliferation of tumor cells

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These methods make it possible to capture nonlinear relationships, which helps to more accurately rebuild disease-specific regulatory networks and predict important functional nodes ( The main translational value of multi-omics integration is that it can find useful biological information