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Key regulatory axesincluding HIF-1, HHIP-PKM2, PTGES-AKT-HIF-1, and lactate/LDH-A (LDH5)-TGF-interact to collectively promote enhanced glycolysis and diminished oxidative metabolism, sustaining the pathological phenotype of the disease ( Abnormalities in the PPP are primarily manifested as oxidative stress-induced compensatory activation

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Springer (2004)

Ther Adv Med Oncol 6(5):229239

Morning exercise can energize the early hours and establish momentum for the day