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For GSD-1b patients poorly respond to regular treatment, somatic gene therapy is becoming an available choice

Seetharam R, Sood A, Goel S (2009) Oxaliplatin: pre-clinical perspectives on the mechanisms of action, response and resistance

J Clin Nutr 7(3):8186

Although biochemically separated from the GSH system, the Trx system shares NADPH as a common reducing cofactor and serves as an alternative pathway for reducing disulfide bonds, making this system especially relevant if the GSH system has been compromised or rendered dysfunctional (Silva-Adaya et al., 2014)

Then, in the early 1990s, a Croatian researcher at the University of Zagreb named Petar Sikiri did something that would eventually shake the biohacking world