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Integration with metabolic therapies: since senescent adipose tissue, liver steatosis and visceral fat contribute to metabolic decline, FOXO4-DRI might improve metabolic resilience

10.1016/j.meafoo.2024.100195 93 KeenumI.WindL.RayP.GuronG.ChenC.KnowltonK.et al (2022)

Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus

For the optic nerve crush rat models, the RGC shows a reduction of GPX4 and SLC7A11 expression, increased membrane density, reduced mitochondrial cristae, and increased lipid peroxide and iron levels, indicating RGC ferroptosis after optic nerve crush (Guo et al., 2022)