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Despite the observed decreases in peripheral blood pressure and PWV, the AIx and central pulse pressure (PP) did not change significantly

Unlike some peptides that tolerate freezer storage, copper peptides undergo structural changes at sub-zero temperatures that dissociate the copper ion from the peptide backbone

These limitations have motivated researchers to investigate alternative delivery methods that can bypass the BBB while ensuring sufficient patient compliance, preferably avoiding invasive routes like injections

The lyophilized vials most users handle are research-grade