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These changes can cause a cascade of oxidative damage that can systemically make its way to the male reproductive system, thereby causing infertility

625 This demonstrates how physiologically relevant metabolic pathways employed by astrocytes for maintaining the homoeostasis of the nervous tissue may acquire detrimental proportions under conditions of excessive or prolonged stress

The symptoms and signs of acromegaly (e.g., arthropathy, carpal tunnel syndrome, generalized visceromegaly, macroglossia, hypertension, glucose intolerance, headache, lethargy, excess perspiration, and sleep apnea) progress slowly, and diagnosis often is delayed

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