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Description

A small fraction is metabolized by cytochrome P450 enzymes (mainly CYP2E1) to form a reactive intermediate, N-acetyl-p-benzoquinone imine (NAPQI), which is then detoxified by conjugation with glutathione

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Studies found that EpCAM-low CTCs had reduced proliferation but increased migration, suggesting these cells have a higher potential for metastasis [6]

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High-throughput in silico docking and structure-based drug design offer powerful approaches to accelerate the discovery of clinically relevant GLO-1 inhibitors