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Cocaine self-administration and extinction leads to reduced glial fibrillary acidic protein expression and morphometric features of astrocytes in the nucleus accumbens core

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165,166 Upon mTORC1 activation, LARP1 is phosphorylated, relieving this repression 167,168 and facilitating the translation of TOP mRNAs via interaction with RAPTOR

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The safety profile of cagrilintide-semaglutide was broadly consistent with that reported for other incretin-based therapies, although gastrointestinal adverse events and treatment discontinuations occurred more frequently than with either semaglutide or cagrilintide alone, highlighting the importance of careful patient selection and long-term adherence